Dr.-Ing.
Dr.-Ing. Robert Heyer
Faculty of Informatics
AG Databases & Software Engineering
AG Databases & Software Engineering
G29-112/ G25-119
Aktuelle Projekte
- Optimizing graph databases focussing on data processing and integration of machine learning for large clinical and biological datasets
Laufzeit: 01.12.2021 - 30.11.2024
Abgeschlossene Projekte
- Integrated Cycles for Urban Biomass (ICU): Optimierung von Biomasseströmen und -verwertungswegen in urbanen Wohngebäuden mit dem Ziel einer CO2-neutralen Stadt
Laufzeit: 01.12.2019 - 28.02.2021 - InflammatorySystems-Microbiome: Systemdiagnostik des menschlichen Darmmikrobioms bei entzündungsbedingten Erkrankungen mittels Metaproteomeanalyse
Laufzeit: 01.10.2017 - 31.10.2018
2021
- Jo De Vrieze, Robert Heyer, Ruben
Props, Lieven Van Meulebroek, Karen Gille, Lynn Vanhaecke, Dirk Benndorf, and
Nico Boon.
Triangulation of microbial fingerprinting in anaerobic digestion
reveals consistent fingerprinting profiles..
Water research, Volume 202, page 117422, September
2021.
- Ronald Biemann, Enrico Buß, Dirk
Benndorf, Theresa Lehmann, Kay Schallert, Sebastian Püttker, Udo Reichl,
Berend Isermann, Jochen G. Schneider, Gunter Saake, and Robert Heyer.
Fecal Metaproteomics
Reveals Reduced Gut Inflammation and Changed Microbial Metabolism Following
Lifestyle-Induced Weight Loss.
Biomolecules, 11(5, ARTICLE-NUMBER = 726),
2021.
- Daniel Walke, Kay Schallert, Prasanna
Ramesh, Dirk Benndorf, Emanuel Lange, Udo Reichl, and Robert Heyer.
MPA_Pathway_Tool:
User-Friendly, Automatic Assignment of Microbial Community Data on Metabolic
Pathways.
International Journal of Molecular Sciences, 22(20, ARTICLE-NUMBER
= 10992), 2021.
- Roman Zoun, Kay Schallert, David
Broneske, Ivayla Trifonova, Xiao Chen, Robert Heyer, Dirk Benndorf, and
Gunter Saake.
An Investigation of
Alternatives to Transform Protein Sequence Databases to a Columnar Index
Schema.
Algorithms, 14(2), 2021.
- Rahul Mondal, Minh Dung Do, Nasim Uddin
Ahmed, David Broneske, Gunter Saake, and Robert Heyer.
Integrating Decision Tree Learning on the Graph Database Neo4j to
Analyze Clinical Data.
In Proceedings of the International Conference on Computational
Intelligence Methods for Bioinformatics and Biostatistics (CIBB),
2021.
2020
- Alberto Scoma, Way Cern Khor, Marta
Coma, Robert Heyer, Ruben Props, Jonas Schoelynck, Tim Bouts, Dirk Benndorf,
Desheng Li, Hemin Zhang, et al.
Substrate-Dependent Fermentation of Bamboo in Giant Panda Gut
Microbiomes: Leaf Primarily to Ethanol and Pith to Lactate.
Frontiers in microbiology, Volume 11, page 530,
2020.
- Robert Heyer, Johanna Klang, Patrick
Hellwig, Kay Schallert, Philipp Kress, Benedikt Huelsemann, Susanne Theuerl,
Udo Reichl, and Dirk Benndorf.
Impact of feeding and stirring regimes on the internal stratification
of microbial communities in the fermenter of anaerobic digestion
plants.
Bioresource Technology, 2020.
- Irena Maus, Tom Tubbesing, Daniel
Wibberg, Robert Heyer, Julia Hassa, Geizecler Tomazetto, Liren Huang, Boyke
Bunk, Cathrin Spröer, Dirk Benndorf, Vladimir Zverlov, Alfred Pühler,
Michael Klocke, and Sczyrba.
The Role of
Petrimonas mucosa ING2-E5AT in Mesophilic Biogas Reactor Systems as Deduced
from Multiomics Analyses.
Microorganisms, 8(12, ARTICLE-NUMBER = 2024),
2020.
2019
- Roman Zoun, Kay Schallert, David
Broneske, Ivayla Trifonova, Xiao Chen, Robert Heyer, Dirk Benndorf, and
Gunter Saake.
Efficient Transformation of Protein Sequence Databases to Columnar
Index Schema.
In International Workshop on Biological Knowledge Discovery and Data
Mining (BIOKDD-DEXA), volume 1062 of CCIS, pages 67–72.
IEEE, August 2019.
- Robert Heyer, Kay Schallert, Corina
Siewert, Fabian Kohrs, J. Greve, I. Maus, J. Klang, M. Klocke, M. Heiermann,
M. Hoffmann, S. Puettker, M. Calusinska, Roman Zoun, Gunter Saake, Dirk
Benndorf, and Udo Reichl.
Metaproteome
analysis reveals that syntrophy, competition, and phage-host interaction
shape microbial communities in biogas plants.
Microbiome, 7(1):69, April 2019.
- Roman Zoun, Kay Schallert, David
Broneske, Wolfram Fenske, Marcus Pinnecke, Robert Heyer, Sven Brehmer, Dirk
Benndorf, and Gunter Saake.
MSDataStream - Connecting a Bruker Mass Spectrometer to the
Internet.
In Datenbanksysteme für Business, Technologie und Web, pages
507 – 510. Gesellschaft für Informatik, March
2019.
- Robert heyer, Kay Schallert, Anja
Buedel, Roman Zoun, Sebastian Dorl, Alexander Behne, Fabian Kohrs, Sebastian
Puettker, Corina Siewert, Thilo Muth, Gunter Saake, Udo Reichl, and Dirk
Benndorf.
A robust and universal
metaproteomics workflow for research studies and routine diagnostics within
24 hours using phenol extraction, FASP digest and the
MetaProteomeAnalyzer.
Frontiers in Microbiology, Volume 10 1883,
2019.
- Roman Zoun, Kay Schallert, David
Broneske, Sören Falkenberg, Robert Heyer, Sabine Wehnert, Sven Brehmer,
Dirk Benndorf, and Gunter Saake.
MStream: Proof of Concept of an Analytic Cloud Platform for
Near-Real-Time Diagnostics using Mass Spectrometry Data.
002-2019, Otto-von-Guericke-University Magdeburg, 2019.
- R. Heyer, K. Schallert, C. Siewert,
F. Kohrs, J. Greve, I. Maus, J. Klang, M. Klocke, M. Heiermann, M. Hoffmann,
S. Puttker, M. Calusinska, R. Zoun, G. Saake, D. Benndorf, and U. Reichl.
Metaproteome analysis
reveals that syntrophy, competition, and phage-host interaction shape
microbial communities in biogas plants.
Microbiome, Volume 7, 2019.
Hv5rv Times Cited:1 Cited References Count:70.
- T. Lehmann, K. Schallert,
R. Vilchez-Vargas, D. Benndorf, S. Puttker, S. Sydor, C. Schulz, L. Bechmann,
A. Canbay, B. Heidrich, U. Reichl, A. Link, and R. Heyer.
Metaproteomics
of fecal samples of Crohn's disease and Ulcerative Colitis.
J Proteomics, Volume 201, pages 93–103, 2019.
Lehmann, T Schallert, K Vilchez-Vargas, R Benndorf, D Puttker, S Sydor, S
Schulz, C Bechmann, L Canbay, A Heidrich, B Reichl, U Link, A Heyer, R eng
Netherlands 2019/04/23 06:00 J Proteomics. 2019 Jun 15;201:93-103. doi:
10.1016/j.jprot.2019.04.009. Epub.
- A. Scoma, R. Heyer, R. Rifai,
C. Dandyk, I. Marshall, F. M. Kerckhof, A. Marietou, H. T. S. Boshker,
F. J. R. Meysman, K. G. Malmos, T. Vosegaard, P. Vermeir, I. M. Banat,
D. Benndorf, and N. Boon.
Reduced TCA
cycle rates at high hydrostatic pressure hinder hydrocarbon degradation and
obligate oil degraders in natural, deep-sea microbial
communities.
ISME J, 13(4):1004–1018, 2019.
Scoma, Alberto Heyer, Robert Rifai, Ridwan Dandyk, Christian Marshall, Ian
Kerckhof, Frederiek-Maarten Marietou, Angeliki Boshker, Henricus T S Meysman,
Filip J R Malmos, Kirsten G Vosegaard, Thomas Vermeir, Pieter Banat, Ibrahim
M Benndorf, Dirk Boon, Ni.
- C. E. Thorn, C. Bergesch, A. Joyce,
G. Sambrano, K. McDonnell, F. Brennan, R. Heyer, D. Benndorf, and F. Abram.
A robust,
cost-effective method for DNA, RNA and protein co-extraction from soil, other
complex microbiomes and pure cultures.
Mol Ecol Resour, 19(2):439–455, 2019.
Thorn, Camilla E Bergesch, Christian Joyce, Aoife Sambrano, Gustavo McDonnell,
Kevin Brennan, Fiona Heyer, Robert Benndorf, Dirk Abram, Florence eng NUI
Galway England 2018/12/20 06:00 Mol Ecol Resour. 2019 Mar;19(2):439-455. doi:
10.1111/1755-0998.12979.
2018
- Roman Zoun, Gabriel Campero Durand, Kay
Schallert, Apoorva Patrikar, David Broneske, Wolfram Fenske, Robert Heyer,
Dirk Benndorf, and Gunter Saake.
Protein Identification as a Suitable Application for Fast Data
Architecture.
In International Workshop on Biological Knowledge Discovery and Data
Mining (BIOKDD-DEXA), pages 168 – 178. IEEE, September
2018.
- Roman Zoun, Kay Schallert, Atin Janki,
Rohith Ravindran, Gabriel Campero Durand, Wolfram Fenske, David Broneske,
Robert Heyer, Dirk Benndorf, and Gunter Saake.
Streaming FDR Calculation for Protein Identication.
In Advances in Databases and Information Systems, pages 80 – 87,
September 2018.
- Atin Janki, Roman Zoun, Kay Schallert,
Rohith Ravindran, David Broneske, Wolfram Fenske, Robert Heyer, Dirk
Benndorf, and Gunter Saake.
Connecting X! Tandem to a Database Management
System.
In GI-Workshop Grundlagen von Datenbanken, GvDB, pages 77–82, May
2018.
- T. Muth, F. Kohrs, R. Heyer,
D. Benndorf, E. Rapp, U. Reichl, L. Martens, and B. Y. Renard.
MPA Portable: A
Stand-Alone Software Package for Analyzing Metaproteome Samples on the
Go.
Anal Chem, 90(1):685–689, 2018.
Muth, Thilo Kohrs, Fabian Heyer, Robert Benndorf, Dirk Rapp, Erdmann Reichl,
Udo Martens, Lennart Renard, Bernhard Y eng U24 CA199347/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
2017/12/08 06:00 Anal Chem. 2018 Ja.
- Lisa Wenzel, Robert Heyer, Kay
Schallert, Lucy Löser, Röbbe Wünschiers, Udo Reichl, and Dirk
Benndorf.
SDS-PAGE fractionation to increase metaproteomic insight into the
taxonomic and functional composition of microbial communities for biogas
plant samples.
Engineering in Life Sciences, Volume 18,
2018.
- R. Zoun, G. C. Durand, K. Schallert,
A. Patrikar, D. Broneske, W. Fenske, R. Heyer, D. Benndorf, and G. Saake.
Protein Identification as a
Suitable Application for Fast Data Architecture.
Database and Expert Systems Applications: Dexa 2018 International
Workshops, Volume 903, pages 168–178, 2018.
Bm1ts Times Cited:1 Cited References Count:30 Communications in Computer and
Information Science.
- R. Zoun, K. Schallert, A. Janki,
R. Ravindran, G. C. Durand, W. Fenske, D. Broneske, R. Heyer, D. Benndorf,
and G. Saake.
Streaming FDR Calculation
for Protein Identification.
New Trends in Databases and Information Systems, Adbis 2018,
Volume 909, pages 80–87, 2018.
Bm5sq Times Cited:1 Cited References Count:20 Communications in Computer and
Information Science.
2017
- Robert Heyer, Kay Schallert, Roman
Zoun, Beatrice Becher, Gunter Saake, and Dirk Benndorf.
Challenges and perspectives of metaproteomic data
analysis..
Journal of biotechnology, Number 261, pages 24–36, 11
2017.
- Roman Zoun, Kay Schallert, David
Broneske, Robert Heyer, Dirk Benndorf, and Gunter Saake.
Interactive Chord Visualization for Metaproteomics.
In International Workshop on Biological Knowledge Discovery and Data
Mining (BIOKDD-DEXA). IEEE, 2017.
www.dxdoi.org/10.1109/DEXA.2017.32.
- R. Heyer, K. Schallert, R. Zoun,
B. Becher, G. Saake, and D. Benndorf.
Challenges and
perspectives of metaproteomic data analysis.
J Biotechnol, Volume 261, pages 24–36, 2017.
Heyer, Robert Schallert, Kay Zoun, Roman Becher, Beatrice Saake, Gunter
Benndorf, Dirk eng Review Netherlands 2017/07/01 06:00 J Biotechnol. 2017 Nov
10;261:24-36. doi: 10.1016/j.jbiotec.2017.06.1201. Epub 2017 Jun
27.
- F. Kohrs, R. Heyer, T. Bissinger,
R. Kottler, K. Schallert, S. Puttker, A. Behne, E. Rapp, D. Benndorf, and
U. Reichl.
Proteotyping of
laboratory-scale biogas plants reveals multiple steady-states in community
composition.
Anaerobe, Volume 46, pages 56–68, 2017.
Kohrs, F Heyer, R Bissinger, T Kottler, R Schallert, K Puttker, S Behne, A
Rapp, E Benndorf, D Reichl, U eng England 2017/02/13 06:00 Anaerobe. 2017
Aug;46:56-68. doi: 10.1016/j.anaerobe.2017.02.005. Epub 2017 Feb
9.
- R. Zoun, K. Schallert, D. Broneske,
R. Heyer, D. Benndorf, and G. Saake.
Interactive Chord
Visualization for Metaproteomics.
2017 28th International Workshop on Database and Expert Systems
Applications (Dexa), 2017.
Bj5nr Times Cited:4 Cited References Count:11 International Workshop on
Database and Expert Systems Applications-DEXA.
2016
- A. Bensmann, R. Hanke-Rauschenbach,
R. Heyer, F. Kohrs, D. Benndorf, R. Kausmann, M. Plochl, M. Heiermann,
U. Reichl, and K. Sundmacher.
Diagnostic concept for
dynamically operated biogas production plants.
Renewable Energy, Volume 96, pages 479–489, 2016.
A Dq5ux Times Cited:12 Cited References Count:25.
- R. Heyer, D. Benndorf, F. Kohrs,
J. De Vrieze, N. Boon, M. Hoffmann, E. Rapp, A. Schluter, A. Sczyrba, and
U. Reichl.
Proteotyping of
biogas plant microbiomes separates biogas plants according to process
temperature and reactor type.
Biotechnol Biofuels, Volume 9, page 155, 2016.
Heyer, R Benndorf, D Kohrs, F De Vrieze, J Boon, N Hoffmann, M Rapp, E
Schluter, Andreas Sczyrba, Alexander Reichl, U eng England 2016/07/28 06:00
Biotechnol Biofuels. 2016 Jul 26;9:155. doi: 10.1186/s13068-016-0572-4.
eCollection 2016.
2015
- R. Heyer, F. Kohrs, U. Reichl, and
D. Benndorf.
Metaproteomics
of complex microbial communities in biogas plants.
Microb Biotechnol, 8(5):749–63, 2015.
Heyer, Robert Kohrs, Fabian Reichl, Udo Benndorf, Dirk eng Research Support,
Non-U.S. Gov't Review 2015/04/16 06:00 Microb Biotechnol. 2015
Sep;8(5):749-63. doi: 10.1111/1751-7915.12276. Epub 2015 Apr
15.
- F. Kohrs, S. Wolter, D. Benndorf,
R. Heyer, M. Hoffmann, E. Rapp, A. Bremges, A. Sczyrba, A. Schluter, and
U. Reichl.
Fractionation of
biogas plant sludge material improves metaproteomic characterization to
investigate metabolic activity of microbial communities.
Proteomics, 15(20):3585–9, 2015.
Kohrs, Fabian Wolter, Sophie Benndorf, Dirk Heyer, Robert Hoffmann, Marcus
Rapp, Erdmann Bremges, Andreas Sczyrba, Alexander Schluter, Andreas Reichl,
Udo eng Research Support, Non-U.S. Gov't Germany 2015/07/15 06:00 Proteomics.
2015 Oct;15(20):3585-9. do.
- T. Muth, A. Behne, R. Heyer, F. Kohrs,
D. Benndorf, M. Hoffmann, M. Lehteva, U. Reichl, L. Martens, and E. Rapp.
The
MetaProteomeAnalyzer: a powerful open-source software suite for
metaproteomics data analysis and interpretation.
J Proteome Res, 14(3):1557–65, 2015.
Muth, Thilo Behne, Alexander Heyer, Robert Kohrs, Fabian Benndorf, Dirk
Hoffmann, Marcus Lehteva, Miro Reichl, Udo Martens, Lennart Rapp, Erdmann eng
Research Support, Non-U.S. Gov't 2015/02/11 06:00 J Proteome Res. 2015 Mar
6;14(3):1557-65. doi: 10.1021/.
- S. Puttker, F. Kohrs, D. Benndorf,
R. Heyer, E. Rapp, and U. Reichl.
Metaproteomics
of activated sludge from a wastewater treatment plant - a pilot
study.
Proteomics, 15(20):3596–601, 2015.
Puttker, Sebastian Kohrs, Fabian Benndorf, Dirk Heyer, Robert Rapp, Erdmann
Reichl, Udo eng Research Support, Non-U.S. Gov't Germany 2015/07/24 06:00
Proteomics. 2015 Oct;15(20):3596-601. doi: 10.1002/pmic.201400559. Epub 2015
Aug 20.
2014
- A. Bensmann, R. Hanke-Rauschenbach,
R. Heyer, F. Kohrs, D. Benndorf, U. Reichl, and K. Sundmacher.
Biological methanation of
hydrogen within biogas plants: A model-based feasibility study.
Applied Energy, Volume 134, pages 413–425, 2014.
Ar1hp Times Cited:38 Cited References Count:24.
- F. Kohrs, R. Heyer, A. Magnussen,
D. Benndorf, T. Muth, A. Behne, E. Rapp, R. Kausmann, M. Heiermann,
M. Klocke, and U. Reichl.
Sample
prefractionation with liquid isoelectric focusing enables in depth microbial
metaproteome analysis of mesophilic and thermophilic biogas
plants.
Anaerobe, Volume 29, pages 59–67, 2014.
Kohrs, F Heyer, R Magnussen, A Benndorf, D Muth, T Behne, A Rapp, E Kausmann, R
Heiermann, M Klocke, M Reichl, U eng Research Support, Non-U.S. Gov't England
2013/12/07 06:00 Anaerobe. 2014 Oct;29:59-67. doi:
10.1016/j.anaerobe.2013.11.009. Epub 2013 Dec.
2013
- A. Hanreich, U. Schimpf, M. Zakrzewski,
A. Schluter, D. Benndorf, R. Heyer, E. Rapp, A. Puhler, U. Reichl, and
M. Klocke.
Metagenome and
metaproteome analyses of microbial communities in mesophilic biogas-producing
anaerobic batch fermentations indicate concerted plant carbohydrate
degradation.
Syst Appl Microbiol, 36(5):330–8, 2013.
Hanreich, Angelika Schimpf, Ulrike Zakrzewski, Martha Schluter, Andreas
Benndorf, Dirk Heyer, Robert Rapp, Erdmann Puhler, Alfred Reichl, Udo Klocke,
Michael eng Research Support, Non-U.S. Gov't Germany 2013/05/23 06:00 Syst
Appl Microbiol. 2013 Jul;36(5).
- R. Heyer, F. Kohrs, D. Benndorf,
E. Rapp, R. Kausmann, M. Heiermann, M. Klocke, and U. Reichl.
Metaproteome
analysis of the microbial communities in agricultural biogas
plants.
N Biotechnol, 30(6):614–22, 2013.
Heyer, R Kohrs, F Benndorf, D Rapp, E Kausmann, R Heiermann, M Klocke, M
Reichl, U eng Research Support, Non-U.S. Gov't Netherlands 2013/02/02 06:00 N
Biotechnol. 2013 Sep 25;30(6):614-22. doi: 10.1016/j.nbt.2013.01.002. Epub
2013 Jan 29.
2012
- A. Hanreich, R. Heyer, D. Benndorf,
E. Rapp, M. Pioch, U. Reichl, and M. Klocke.
Metaproteome
analysis to determine the metabolically active part of a thermophilic
microbial community producing biogas from agricultural biomass.
Can J Microbiol, 58(7):917–22, 2012.
Hanreich, Angelika Heyer, Robert Benndorf, Dirk Rapp, Erdmann Pioch, Markus
Reichl, Udo Klocke, Michael eng Research Support, Non-U.S. Gov't Canada
2012/06/14 06:00 Can J Microbiol. 2012 Jul;58(7):917-22. doi:
10.1139/w2012-058. Epub 2012 Jun 12.
- Software and database development for analysis of complex microbial communities
- Metaproteome analysis
- Human gut microbiome
Methoden der Proteinanalytik